505,538 Result(s)
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Chapter
Introduction: A Short History of Adrenoceptor Research
This chapter provides a short history of adrenoceptor research starting from the initial discovery of adrenaline. It covers the evolving classification of adrenoceptor subtypes, the cloning of these subtypes f...
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Chapter
Aging Brain from a Lifespan Perspective
Research during the last two decades has shown that the brain undergoes continuous changes throughout life, with substantial heterogeneity in age trajectories between regions. Especially, temporal and prefront...
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Chapter
In Vivo and Clinical Studies of Natural Products Targeting the Hallmarks of Cancer
Despite more than 200 approved anticancer agents, cancer remains a leading cause of death worldwide due to disease complexity, tumour heterogeneity, drug toxicity, and the emergence of drug resistance. Accordi...
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Endocrine Control of Lipid Metabolism
Lipids are essential in insects and play pleiotropic roles in energy storage, serving as a fuel for energy-driven processes such as reproduction, growth, development, locomotion, flight, starvation response, a...
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Transcriptional Control of Lipid Metabolism
Transcriptional control of lipid metabolism uses a framework that parallels the control of lipid metabolism at the protein or enzyme level, via feedback and feed-forward mechanisms. Increasing the substrates f...
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The Logic and History of Passive Immunity and Antibody Therapies
This volume takes a broad overview of antibody-based therapies prior to and during the COVID pandemic and examines their potential use in future pandemics. Passive antibody therapy was the first effective anti...
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Blood Banking Capacity in Low-and Middle-Income Countries: Covid-19 Convalescent Plasma in Context
Blood transfusion capacity in low- and middle-income countries (LMICs), encompassing both the safety and adequacy of the blood supply, is limited. The challenges facing blood banks in LMICs include regulatory ...
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Chapter
Bioactive Flavonoids in Protecting Against Endothelial Dysfunction and Atherosclerosis
Atherosclerosis is a common cardiovascular disease closely associated with factors such as hyperlipidaemia and chronic inflammation. Among them, endothelial dysfunction serves as a major predisposing factor. V...
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Dissociative Symptoms and Interoceptive Integration
Dissociative symptoms and disorders of dissociation are characterised by disturbances in the experience of the self and the surrounding world, manifesting as a breakdown in the normal integration of consciousn...
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Presynaptic Adrenoceptors
Presynaptic α2-adrenoceptors are localized on axon terminals of many noradrenergic and non-noradrenergic neurons in the peripheral and central nervous systems. Their activation by exogenous agonists leads to inhi...
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Predictive Processing and the Pathophysiology of Functional Neurological Disorder
The contemporary neuroscience understanding of the brain as an active inference organ supports that our conscious experiences, including sensorimotor perceptions, depend on the integration of probabilistic pre...
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Chapter
Correction to: Antifungal Stewardship in Invasive Fungal Infections, a Systematic Review
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Perceptual Dysfunction in Eating Disorders
Eating disorders (EDs) are characterized by abnormal responses to food and weight-related stimuli and are associated with significant distress, impairment, and poor outcomes. Because many of the cardinal sympt...
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Visual Perceptual Processing Abnormalities in Body Dysmorphic Disorder
Phenomenological observations of individuals with body dysmorphic disorder (BDD), coupled with evidence from neuropsychological, psychophysical, and neuroimaging studies, support a model of aberrant visual per...
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Integrating the Physical Environment Within a Population Neuroscience Perspective
Population neuroscience recognises the role of the environment in shaping brain, behaviour, and mental health. An overview of current evidence from neuroscientific and epidemiological studies highlights the pr...
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Chapter
Plant Hormone Crosstalk Under Abiotic Stress Conditions
Plants are constantly challenged by a wide range of adverse conditions in their ever-changing environment. Abiotic stresses, including drought, heat, cold, and salinity, are among the main stress cues that neg...
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The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations
In the aftermath of psychological trauma, many individuals experience perturbations in interoception, a term that broadly references the ability to accurately detect body signals and integrate these signals wi...
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Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration
Recent integrative multilevel models offer novel insights into the etiology and course of neurodegenerative conditions. The predictive coding of allostatic-interoception theory posits that the brain adapts to ...
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Halophytes and Climate Change: Elucidation of Salt-Tolerance Mechanisms and Biodiversity Conservation
The progressive secondary salinisation of irrigated farmland, mostly caused by accumulation in the soil of toxic ions dissolved in the irrigation water and accelerated by climate change, is a major contributor...
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Population Neuroscience: Principles and Advances
In population neuroscience, three disciplines come together to advance our knowledge of factors that shape the human brain: neuroscience, genetics, and epidemiology (Paus, Human Brain Mapping 31:891–903, 2010)...
